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. 2017 May 22;7:2215. doi: 10.1038/s41598-017-02509-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A proposed model of serotonergic descending modulation of spinal somatosensation. In young animals (P21), descending serotonergic modulation facilitates tactile and noxious inputs to the dorsal horn via activation of 5-HT₃Rs. In adults, descending serotonergic and 5-HT₃R-mediated facilitation of tactile inputs is also observed; however, noxious inputs are now inhibited by descending serotonergic neurons via a different 5-HTR subtype.