Fig. 5.

Ischemia-induced arteriogenesis and angiogenesis are impaired in Cav-1 TG mice. (A and B) Arteriectomy was performed in Cav-1 TG and WT mice, and blood flow (A) and clinical index (B) were quantified over time. Data are mean ± SEM (n = 6). (C) The inflamed, necrotic foot seen in nonischemic (Upper Left) and ischemic (Upper Right) Cav-1 TG mice, compared with littermate controls (Lower). (D) The reduction in blood-flow recovery and clinical outcome were attributable to a decrease in lower-limb angiogenesis. Data are mean ± SEM, with n = 6 animals per group. Four fields per section and five sections per animal were quantified. *, P < 0.05.