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PrP deposition in the cerebellum of Tg(PG14) mice is not affected by Bax status. Sections from mice of the following genotypes, ages, and health status were stained with anti-PrP antibody and lightly counterstained with hematoxylin: Tg(PG14)/Bax+/- (134 days, healthy) (A); Tg(PG14)/Bax-/- (134 days, healthy) (B); Tg(PG14)/Bax+/- (320 days, terminal) (C); and Tg(PG14)/Bax-/- (323 days, terminal) (D). gr, granule cell layer; mo, molecular layer. (Scale bar: 50 μm.)
