Table 1. Pluripotency of normal MSCs and CFTR-corrected CF MSCs.
Mean % from three CF donors†
|
||||
---|---|---|---|---|
Cells | CFU,* % | Adipogenic | Osteogenic | Chondrogenic |
Normal MSCs | 42 ± 8 | 35 ± 7 | 70 ± 12 | 24 ± 9 |
CFTR+ CF MSCs | 29 ± 10 | 23 ± 5 | 86 ± 18 | 28 ± 11 |
Mean ± SE of clonal populations isolated from 100 MSCs plated
Mean ± SE of differentiated cells along each lineage after MSCs placed in specific lineage-induction media