Table 1.
Summary of dose-response analysis data for α2, α2β, α2R323L and α2R323Lβ Glycine receptors (GlyRs).
α2 | α2β | α2R323L | α2R323Lβ | |
---|---|---|---|---|
EC50 μM | 46.6 ± 6.7 | 90.3 ± 14.6 | 67.9 ± 13.4 | 143.0 ± 12.9* |
Hill slope | 2.2 ± 0.1 | 2.1 ± 0.1 | 2.1 ± 0.2 | 2.0 ± 0.3 |
Imax (nA) | 1.6 ± 0.2 | 2.1 ± 0.3 | 1.5 ± 0.4 | 1.7 ± 0.2 |
n | 12 | 11 | 9 | 13 |
Statistical comparisons of α2R323L and α2R323Lβ were made relative to α2 and α2β GlyRs, respectively, via an unpaired Student’s t-test. *p < 0.05.