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. 2017 May 23;11:139. doi: 10.3389/fncel.2017.00139

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Copyright © 2017 Teissier, Soiza-Reilly and Gaspar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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5-hydroxytryptamine (5-HT)-depletion in the tryptophan hydroxylase 2 (Tph2)-KO mouse modifies the terminal innervation of 5-HT neurons from dorsal raphe, B7 and median raphe, B8 (Migliarini et al., 2013). The green shading shown in the control brain, corresponds to areas where modified 5-HT innervation was observed in the Tph2-KO mice (red, increased; yellow, decreased). An increased density of 5-HT terminals (red shading) was noted in the hippocampus (Hip) coinciding with a decreased innervation (yellow shading) of the thalamic paraventricular (PV) nucleus and the suprachiasmatic (SCh) nucleus. No difference in 5-HT fiber density was observed in the cortex or the olfactory bulb (OB) of the Tph2-KO. Similar observations were made after adult knockdown of Tph2 (Pratelli et al., 2017).