Table 1.
Known gD and gB receptors for HSV-1
| Receptor | Gene/protein symbol | Aliases | Protein Family | Tissue expressiona |
|---|---|---|---|---|
| gD receptors | ||||
| Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator, HVEM) | TNFRSF14 | ATAR, CD270, HVEA, HVEM, LIGHTR, TR2 | TNF receptor superfamily | Immune cells, broadly expressed |
| Poliovirus receptor-like 1 (herpesvirus entry mediator C) | PVRL1 | NECTIN1, CD111, CLPED1, ED4, HIgR, HVEC, OFC7, PRR, PRR1, PVRR, SK-12 | Immunoglobulin superfamily | Epithelial cells, broadly expressed |
| gB receptors | ||||
| Paired immunoglobulin-like type 2 receptor α | PILRA | FDF03 | Immunoglobulin superfamily | Gastrointestinal tract, genital tract, lung |
| Myelin-associated glycoprotein | MAG | GMA, SIGLEC-4A, S-MAG | Myelin protein family | Brain |
| Myosin heavy chain 9, non-muscle | MYH9 | DFNA17, FTNS, EPSTS, NMMHC-IIA | Myosin protein family | Bone marrow, lung, GI tract, genital tract |
aBodywide tissue distribution profiles were determined using publicly available databases at https://www.ncbi.nlm.nih.gov/geoprofiles, https://www.ebi.ac.uk/gxa/home, and http://biogps.org