Table 1.

Principal roles of NPs in CV homeostasis and metabolism

	ANP	BNP
Metabolic effects	- Increased lipolysis through HSL, Perilipin, ATGL - Increased browning of white adipocytes via UCP1, PGC1alpha - Decreased inflammatory cytokines and increased adiponectin - Type 2 Diabetes/Insulin resistance - Induced mitochondrial biogenesis (CYTO C)	- Increased lipolysis through HSL, Perilipin, ATGL - Increased browning of white adipocytes via UCP1, PGC1alpha, irisin - Decreased inflammatory cytokines and increased adiponectin - Type 2 Diabetes/Insulin resistance - Induced adipocytes and muscle mitochondrial biogenesis (CYTO C) and lipid oxidation rate - Appetite/satiety (ghrelin)
Cardiovascular effects	- Increased renal perfusion, GFR and natriuresis - Arterial and venous dilation - RAAS inhibition - SNS inhibition - Vasopressin inhibition - Myocardial relaxation - Cardiac anti-fibrotic and anti-hypertrophic effects - Increased vascular permeability - Vascular anti-fibrotic and anti-hypertrophic effects - Anti-atherosclerotic properties	- Increased renal perfusion, GFR and natriuresis - Arterial and venous dilation - RAAS inhibition - SNS inhibition - Vasopressin inhibition - Myocardial relaxation - Cardiac anti-fibrotic and anti-hypertrophic effects