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. 2016 Dec 9;30(3):227–237. doi: 10.1007/s10334-016-0599-3

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Results after each step of CASCADE. Step 1 results after thresholding, Step 2 results after second thresholding and morphological filter, Step 3 testing all voxels in the results of Step 2 against the statistical definition of WMH to generate the WMH confidence map, Step 4 thresholding WMH confidence map at the desired level to produce a binary WMH mask