Table 1.
List of oncolytic viruses currently being tested in clinical trial.
| Virus | Name | Phase | Tumor | Combination | Reference |
|---|---|---|---|---|---|
| Adenovirus | ONYX-015 | III | Squamous cell carcinoma head and neck (SCCHN) | Cisplatin | Khuri et al. (4) |
| I/II | Pancreatic cancer | Gemcitabine | Hecht et al. (5) | ||
| Pilot | Advancer cancers | Irinotecan + 5-FU or IL-2 | Nemunaitis et al. (6) | ||
| I/II | Advanced sarcoma | Mitomycin-C, doxorubicin, cisplatin | Galanis et al. (7) | ||
| Oncorine (H101) | III | SCCHN or esophageal cancer | 5-fluorouracil + cisplatin or adriamycin | Xia et al. (8) | |
| Ad5-CD/Tkrep | I | Prostate cancer | 5-fluorocytosine, valganciclovir, radiation | Freytag et al. (9) | |
| ONCOS-201 | I | Solid tumors | Cyclophosphamide | Ranki et al. (10) | |
| Herpes simplex virus | Talimogene laherparepvec | I/II | SCCHN | Radiation, cisplatin | Harrington et al. (11) |
| Ib | Melanoma | Ipilimumab (CTLA-4 inhibitor) | Puzanov et al. (12) | ||
| G207 | I | Glioma | Radiation | Markert et al. (13) | |
| Reovirus | RT3D | I/II | Advanced cancers | Carboplatin/paclitaxel | Karapangiotou et al. (14) |
| Vaccinia | GL-ONC1 | I | Head and neck carcinoma | Cisplatin, radiotherapy | NCT01584284 |
| JX-594 (Pexa-Vec) | I/IIa | Colorectal cancer | Irinotecan | NCT01394939 | |