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. 2017 May 23;8:596. doi: 10.3389/fimmu.2017.00596

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Copyright © 2017 Zheng, Huang, Ge, Yang, Ma, Xie, Wang, Bian, Li, Nie and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Arginine N-methyltransferase inhibitor 1 (AMI-1) treatment upregulates Treg function in vivo. Colitis was induced in C57BL/6 mice by 3% dextran sulfate sodium. Then, the mice received PBS or 200 mg AMI-1/kg/day intraperitoneally for 7 days. Disease progression was monitored by (A) body weight loss, (B) colitis score, and (C) histology. The numbers in parentheses indicate the number of mice. (D) Colon tissue from the PBS or AMI-1 treatment was cultured for 24 h and the culture medium was collected, the levels of IL-1β,IL-6 and TNFα were measured by ELISA. (E) The Foxp3 expression levels in the spleen (SP) and mesenteric lymph node and Peyer’s patch cells were measured with FACS. (F) An in vitro Treg suppression assay was utilized (Treg:Teff = 1:1). The CFSE dilution in the Teff cells is shown at 72 h. Combined data from three independent experiments are presented.