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. 2017 May 23;8:285. doi: 10.3389/fphar.2017.00285

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Copyright © 2017 Gustafson, Mamo, Shogren, Maran and Yaszemski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Topflash luciferase activity and Axin2 mRNA indicate inhibition of Wnt signaling (A). Luciferase activity of Topflash reporter-transfected 143b-wt (left) and U2OS (right) cell line following 24 h treatment with FH535. (n = 6). (B) Expression of Axin2 mRNA after 24 h treatment with FH535 in 143b-wt, U2OS, and 143b-DxR cell lines. (n = 3). Data information: Data are presented as mean, ±SD. Statistical significance determined by one-way ANOVA with Tukey’s multiple comparison test, ^∗∗indicates p < 0.01, ^∗∗∗∗ indicates p < 0.0001, “n.s.” indicates no statistically significant difference.