Table 4.

Proposed diagnostic criteria for AIDS-related PML-IRIS.

(i)HIV infection (ii)Close temporal relationship between cART initiation and disease onset (iii)cART resulting in a decrease in plasma HIV VL > 1 log10 at the onset or worsening of neurological symptoms (iv)Diagnosis of PML by detection of JCV DNA in CSF or brain tissue (v)Evidence of an inflammatory reaction demonstrated by MRI and/or CNS histopathology (vi)Symptoms could not be explained by a newly acquired infection, the expected course of PML or another opportunistic infection or drug toxicity