Table 1.
Summary of weight gain and baseline blood glucose in rats. Data from control (Sham and UNx Veh), diabetic (UNx STZ Veh) and P2X7Ri groups at doses stated. Measurements were made at 0 and 12 weeks.
| Sham (n = 8) | UNx Veh (n = 8) | UNx STZ Veh (n = 8) | P2X7Ri (10 mg/kg; n = 8) | P2X7Ri (50 mg/kg; n = 9) | |
|---|---|---|---|---|---|
| Wk 0 Weight (g) | 223.8 ± 12.5 | 218.8 ± 17.2 | 217.2 ± 13.3 | 215.3 ± 7.4 | 224.4 ± 10.3 |
| % weight gain (Wk 0 to Wk12) | 84.0 ± 15.8 | 84.9 ± 18.7 | 18.5 ± 8.6a,b | 23.3 ± 6.1a,b | 25.0 ± 10.8a,b |
| Wk 0 BG (mmol/l) |
4.8 ± 0.8 | 5.8 ± 0.8 | 5.1 ± 0.6 | 5.7 ± 1.5 | 6.0 ± 1.1 |
| Kidney weight: body weight (mg/kg) | 2.70 ± 0.29 | 3.95 ± 0.23c | 8.17 ± 0.85a,b | 7.88 ± 0.89a,b | 7.24 ± 0.98a,b |
a,b
P < 0.001 vs Sham or UNx Veh.
c
P < 0.01 vs Sham.