Fig. 1.

Intratumor heterogeneity in kidney cancer revealed by metabolomics analysis (a) Heat map of representative metabolites, with MC1- and MC2-specific features. The log₂ (tumor/normal) values of metabolites were used for the construction of the heat map. Sample names are expressed as patient number and K (tumor) followed by sample site designated in Fig. 1b and S1d. (b) Regions harvested from a nephrectomy specimen from patient no. 33, together with the tissue levels of representative metabolites and mutation status. The metabolite levels are expressed as the tumor/normal ratio.