Fig. 4.

An MPC inhibitor suppresses cancer cell growth. (a) 5K and 5KN cells (n = 3) were seeded in 96-well plates at the density of 2500 cells/well. UK-5099 was added the next day, and cell viability was assessed after 5 d. Values are normalized to the control group (100%). Data represent the mean ± SD. **p < 0.005, by Williams' test. (b) Mice (n = 5) bearing tumors established from patient no. 24 were treated daily with 100 mg/kg of UK-5099. Mice (n = 6) bearing tumors established from patient no. 34 were treated twice daily with 10 mg/kg or daily with 100 mg/kg of UK-5099. Left, tumor volume; right, body weight. Data represent the mean ± SD. *p < 0.05 by Welch's t-test; ##p < 0.01 by Dunnett's test.