Fig. 5.

Metabolic pattern and drug sensitivity. (a) Metabolite levels and anti-tumor activity of temsirolimus in patient-derived xenograft tumors from patients no. 11 (n = 4) and 12 (n = 5). Metabolite levels were measured in tumors without drug treatment (top). Mice bearing tumors were treated weekly with 10 mg/kg of temsirolimus (bottom). Data represent the mean ± SD. *p < 0.05 by Welch's t-test. F1,6P, Fructose 1,6-bisphosphate; Ru5P, ribulose-5-phosphate. (b) Metabolite levels in patient-derived xenograft tumors from patients no. 11 (n = 4) and 12 (n = 5) after once-weekly treatment with 10 mg/kg of temsirolimus. Tumor samples were taken 24 h after the last administration. Data represent the mean ± SD. *p < 0.05, **p < 0.01 by Welch's t-test.