Table 3.

Gene expression correlates with CDKN2A DMR methylation in the GUSTO cohort. Methylation levels of the 9 CDKN2A DMR CpGs were correlated with expression levels (dCt values from RT-PCR) of the different ANRIL transcript variants, p14^ARF and p16^INK4a using linear regression, adjusted for gender and ethnicity; n = no. of subjects.

CpG cluster	ANRIL (linear)		ANRIL (circular)		ANRIL (unspliced)		p14ARF		p16INK4a
	n	p-Value	n	p-Value	n	p-Value	n	p-Value	n	p-Value
1–2	174	0.06	116	0.539	174	0.70	174	0.98	137	0.07
3	167	0.24	110	0.940	167	0.27	167	0.78	130	0.06
4–8	180	0.02	118	0.051	180	0.06	180	0.91	142	0.95
9	106	0.16	81	0.111	106	0.02	107	0.05	91	0.01

Results in bold have a significance ≥ 0.05