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. 2017 Apr 5;19:107–118. doi: 10.1016/j.ebiom.2017.03.045

Fig. 5.

Fig. 5

Ebola GP-specific T-cell responses. Kinetics of antigen-specific CD8+ T-cell responses. a) Four different peptide pools (GP1a, GP1b, GP2, SP) that cover the whole Ebola GP protein (Kikwit) were used for PBMC stimulation. Graphs represent frequencies (%) of total cytokine responses of CD8+ T cells (IFNγ, TNFα, IL2, MIP1β). Each dot represents one subject. (3 × 105 PFU: n = 10; 3 × 106 PFU: n = 7; 2 × 107 PFU: n = 8) (Box and Whiskers, Min to Max, Line: median) b) Fold induction of total cytokines of CD8+ T cells from day 0 to day 56 (Bar graph, line: median value). c) Piecharts represent composition of cytokines induced by all four peptide pools. They show the average values of CD8+ T-cell responses of day 56 of the 2 × 107 PFU dose cohort.