Fig. 6.

CTL-responses following rVSV-ZEBOV vaccination. a) Degranulation of CD8⁺ T cells was measured by CD107a staining. Graphs depict the sum of frequency of CD107a expression induced by all four peptide pools (GP1a, GP1b, GP2, SP) (Box and Whiskers, Min to Max, Line: median). b) The breadth of peptide pool responses increases by vaccine dose. An assay response was determined by 3-fold over the background. The darker the grey, the more peptide pool responses, the higher the breadth of response. Statistical analysis was performed using Mann-Whitney-Wilcoxon test (*p < 0.05; **p < 0.01; ***p < 0.005).