Fig. 7.

PBMCs induce broad cytokine profile following stimulation with Ebola GP peptide pools. a) PBMCs were stimulated with two peptide pools (MP1, MP2 (Appendix Table 5)) that cover the whole Ebola GP (Kikwit). Following 16 h stimulation, supernatants of both stimulations were pooled together and a 27-plex LUMINEX assay was performed (blue: high expression, green: low expression). b) TH1-belonging cytokines are induced in subjects immunized with 2 × 10⁷ PFU. Graphs depict the cytokines IL2 (upper left graph), IL7 (upper right graph), IL15 (middle left graph), IFNγ (middle right graph) and TNFα (lower left graph) (Box and Whiskers, Min to Max, Line: median). Statistical analysis was performed using Mann-Whitney-Wilcoxon test (*p < 0.05; **p < 0.01; ***p < 0.005).