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CD6 Y629 binds directly to the SH2 domains of GADS, GRB2, and TSAd. Equilibrium binding fitted curves and KDs (left) were derived from the sensorgram data (right) for 2-fold serial dilutions of GADS (35 μM) (A), GRB2 (106 μM) (B), and TSAd (314 μM) (C) SH2 domains over immobilized peptides. Background signals for proteins over streptavidin were subtracted.
