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GADS SH2 and SLP-76 SH2 are specific for CD6 Y629 and Y662, respectively. Equilibrium binding fitted curves and KDs (left) were derived from SPR sensorgram data (right) for 2-fold serial dilutions of GADS (10 μM) (A) and SLP-76 (20 μM) (B) SH2 domains over the long CD6 peptides. There was no binding of the GADS SH2 domain to pY662 or of the SLP-76 SH2 domain to pY629 (data not shown). Background signals for proteins over streptavidin were subtracted.
