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Model for bivalent recruitment of the GADS/SLP-76 complex by CD6. The GADS and SLP-76 SH2 domains bind to the phosphorylated tyrosine residues Y629 and Y662, respectively. The C-terminal SH3 domain of GADS binds to a proline-rich region of SLP-76, and we provide evidence that the GADS/SLP-76 complex binds bivalently to the CD6 C terminus.
