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. 2017 May 16;37(11):e00536-16. doi: 10.1128/MCB.00536-16

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Copyright © 2017 O'Neil et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Expression of TNF, IL-10, IL-6, and IL-12p40 proteins by Zfp36^+/+ and Zfp36^aa/aa M-BMMs. Matched Zfp36^+/+ and Zfp36^aa/aa M-BMMs were cultured in 24-, 12-, or 6-well dishes and stimulated with 10 ng/ml LPS for 4 h. ELISAs or multiplex bead assays were used to measure TNF (A), IL-10 (B), IL-6 (C), and IL-12p40 (D) levels. In the cases of TNF and IL-6, 5 of 14 experiments employed matched Zfp36^+/+ and Zfp36^aa/aa littermates. All other experiments employed at least three mice of each genotype, with mean cytokine concentrations being plotted. Cytokine quantities expressed by matched Zfp36^+/+ and Zfp36^aa/aa M-BMMs or sets of M-BMMs are connected by lines. The graphs on the right show mean cytokine expression levels in Zfp36^aa/aa M-BMMs relative to those in matched Zfp36^+/+ controls. n.s., not statistically significant; ***, P < 0.005; **, P < 0.01 (by a Wilcoxon matched-pair test).