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. 2017 May 15;8:15230. doi: 10.1038/ncomms15230

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Copyright © 2017, The Author(s)

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(a) The expression pattern of R27G01-GAL4 (green). The brain was immunostained with DLG antibody (magenta). White arrowheads indicate the somas of MB-M6. Scale bar, 20 μm. (b) The expression pattern of E1255-GAL4 (green). The brain was immunostained with DLG antibody (magenta). White arrowheads indicate the somas of MB-M6. Scale bar, 20 μm. (c) Blocking MB-M6 neurons (R27G01-GAL4) output using shi^ts during retrieval but not during acquisition and consolidation, impaired LTM. Each value represents mean±s.e.m. (N=8, 8, 8, 9, 9, and 9 from left to right bars). *P<0.05; analysis of variance (ANOVA) followed by Tukey's test. (d) Blocking MB-M6 neurons (E1255-GAL4) output using shi^ts during retrieval but not during acquisition and consolidation, impaired LTM. Each value represents mean±s.e.m. (N=10, 10, 10, 9, 9, and 9 from left to right bars). *P<0.05; ANOVA followed by Tukey's test. (e) Adult-stage-specific knockdown of VGlut in MB-M6 neurons (R27G01-GAL4) impaired LTM. Each value represents mean±s.e.m. (N=8). *P<0.05; ANOVA followed by Tukey's test. (f) The expression pattern of G0239-GAL4 (green). The brain was immunostained with DLG antibody (magenta). White arrowheads indicate the somas of MB-V3. Scale bar, 20 μm. (g) The expression pattern of MB082C-GAL4 (green). The brain was immunostained with DLG antibody (magenta). White arrowheads indicate the somas of MB-V3. Scale bar, 20 μm. (h) Blocking MB-V3 neurons (G0239-GAL4) output using shi^ts during retrieval but not during acquisition and consolidation, impaired LTM. Each value represents mean±s.e.m. (N=8, 7, 7, 6, 6 and 7 from left to right bars). *P<0.05; ANOVA followed by Tukey's test. (i) Blocking MB-V3 neurons (MB082C-GAL4) output using shi^ts during retrieval but not during acquisition and consolidation, impaired LTM. Each value represents mean±s.e.m. (N=8). *P<0.05; ANOVA followed by Tukey's test. (j) Adult-stage-specific knockdown of ChAT in MB-V3 neurons (G0239-GAL4) impaired LTM. Each value represents mean±s.e.m. (N=9). *P<0.05; ANOVA followed by Tukey's test.