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(a) Schematic illustration shows that ATP disrupts the ESA-deacetylase domain interaction leading to a more extended form. NTD, deacetylase domain (green box), CTD and ESA are shown. (b,c) Sedimentation velocity analysis of purified recombinant full-length Sirt1 protein. Normalized interference c(s) profiles for solutions of Sirt1 with 20 mM MgCl2 and either (b) 10 mM NAD+ or (c) 10 mM ATP.
