TABLE 4.
Infection of GHOST-CX3CR1 cellsa
| Virus | RTCN value
|
||
|---|---|---|---|
| Parental | CCR5 | CX3CR1 | |
| Aviremic individuals | |||
| RH2-3 3B3 | − | 1,036 | 31 |
| RH2-3 3C3 | − | 973 | 64 |
| RH2-3 6C6 | − | 540 | − |
| RH2-3 8A5 | − | 1,144 | 65 |
| RH2-13 1D4 | − | 1,359 | 16 |
| RH2-13 5C3 | − | 1,326 | 10 |
| RH2-13 6A3 | − | 900 | 8 |
| RH2-14 1A6 | − | 562 | − |
| RH2-14 1B1 | − | 519 | − |
| RH2-14 2A2 | − | 660 | − |
| RH2-14 2A4 | − | 835 | − |
| RH2-22 1B4 | − | 385 | − |
| RH2-22 1C3 | − | 748 | 10 |
| RH2-22 1B2 | 24 | 1,689 | 55 |
| RH2-22 2B2 | − | 1303 | − |
| RH2-4 4D1 | − | 351 | 10 |
| Viremic individuals | |||
| RH2-15 B9 | − | 642 | 10 |
| RH2-15 E5 | − | 561 | − |
| RH2-15 H11 | − | 1,114 | − |
| RH2-1 A8 | − | 125 | − |
| RH2-1 D8 | − | 254 | − |
| RH2-1 G7 | − | 241 | − |
| RH2-5 1F10 | − | 370 | 10 |
| RH2-5 2C8 | − | 728 | 18 |
| RH2-5 2D11 | − | 239 | − |
| RH2-7 B3 | 25 | 619 | 63 |
| RH2-7 F3 | − | 1,056 | 10 |
| RH2-7 F4 | − | 625 | 11 |
| RH2-24 1E2 | − | 1,303 | 15 |
| RH2-24 2D7 | − | 827 | 17 |
| RH2-24 2E10 | − | 565 | − |
| RH2-26 1C1 | − | 1,201 | − |
| RH2-26 2B4 | − | 1,529 | − |
| Controls (CoR) | |||
| ACH337 (R5) | − | 938 | − |
| SIVrcm (X3R1) | − | − | 1,079 |
a
Infection of GHOST-CX3CR1 cells was tested in a separate assay. Parental GHOST cells and GHOST-CCR5 cells were included as control cell lines. SIVrcm was previously shown to be capable of using CX3CR1 (60) and was included as a positive control; an R5 HIV-1 variant was included as a negative control. RTCN values of <5 are considered negative (−).