TABLE 5.
Coreceptor usage of variants with GHOST.CD4 tropism
| Virus | Typea | RTCN value
|
||||||
|---|---|---|---|---|---|---|---|---|
| CCR1 | CCR2b | CCR3 | CCR5 | CXCR4 | GPR15 | CXCR6 | ||
| Aviremic individuals | ||||||||
| RH2-3 3A3 | I | − | − | − | 1,436 | − | 2,614 | 286 |
| RH2-13 6A2 | I | − | − | − | 1,830 | − | 3,795 | 171 |
| RH2-13 6B1 | I | − | − | − | 1,043 | − | 1,995 | 524 |
| RH2-22 2A4 | I | − | − | − | 716 | − | 151 | 155 |
| RH2-22 1B1 | I | 30 | − | − | 1,542 | − | 1,273 | 314 |
| RH2-22 1B2 | I | 1 | − | − | 1,165 | − | 714 | 116 |
| RH2-22 2C2 | I | − | − | − | 921 | − | 277 | 96 |
| RH2-8 3D5 | I | − | − | − | 643 | − | 13 | 2 |
| RH2-4 3B1 | I | − | − | − | 1,138 | − | 159 | 524 |
| RH2-4 4B2 | I | 5 | − | − | 1,280 | − | 774 | 280 |
| Viremic individuals | ||||||||
| RH2-5 2F10 | I | − | − | − | 2,562 | − | 3,423 | 793 |
| RH2-7 B3 | I | − | − | − | 624 | − | 1,175 | 128 |
| RH2-21 2B2 | II | − | − | − | − | 352 | − | − |
| RH2-21 2F9 | II | − | − | − | − | 396 | − | − |
| RH2-24 2D8 | II | − | − | − | − | 1,650 | − | − |
| RH2-24 2E8 | II | − | − | − | − | 510 | − | − |
| RH2-24 2G7 | II | − | − | − | − | 1,891 | − | − |
| RH2-24 2H11 | II | − | − | − | − | 110 | − | − |
| RH2-26 2D9 | II | − | − | − | − | 1,915 | − | − |
| RH2-26 2E9 | II | − | − | − | − | 1,422 | − | − |
| Control virus | ||||||||
| ACH39 X4R3 | II | − | 175 | − | 680 | − | − | |
a
Coreceptor usage was deduced for T22 insensitive variants (I) by subtracting 1.5 times the value of parental cells from that of coreceptor-transduced cells (values from Table 3), and for T22 sensitive variants (II) by translating the effect of T22 (values from Fig. 3). RTCN values <1.5 times that in the parental cells (I) or <5 in the presence of T22 (II) are considered negative (−).