Table 3. Candidate mutant Kras transcriptome signature.

Gene symbol	Gene name	ΔGE LLC*	ΔGE MC38*	ΔGE AE17*
Asns	Asparagine synthetase	+12.7	+11.6	+11.2
Bcat1	Branched chain aminotransferase 1, cytosolic	+11.2	+17.6	+12.2
Casp3	Caspase 3	+12.7	+16.0	+17.4
Ccl2	Chemokine (C–C motif) ligand 2	+85.4	+119.3	+97.7
Ccl7	Chemokine (C–C motif) ligand 7	+11.3	+14.4	+17.8
Cep170	Centrosomal protein 170	+15.3	+11.6	+13.5
Dab2	Disabled 2, mitogen-responsive phosphoprotein	+12.7	+18.2	+10.4
Dusp9	Dual specificity phosphatase 9	+13.1	+15.5	+17.0
Gm10717	Predicted gene 10717	+10.9	+33.3	+45.6
Gm10721	Predicted gene 10721	+10.9	+15.1	+31.4
Gm10722	Predicted gene 10722	+15.2	+241.9	+60.5
Gm26523	Predicted gene, 26523	+56.3	+52.0	+36.4
Gpr149	G protein-coupled receptor 149	+33.1	+33.9	+12.5
Hist1h1b	Histone cluster 1, H1b	+42.9	+50.3	+48.2
Hjurp	Holliday junction recognition protein	+10.3	+14.4	+11.3
Lhfp	Lipoma HMGIC fusion partner	+24.9	+27.2	+23.5
Mpp1	Membrane protein, palmitoylated	+10.6	+16.3	+21.3
Nid1	Nidogen 1	+13.6	+16.0	+15.0
Nid1	Nidogen 1	+10.3	+15.2	+11.3
Prrx1	Paired related homeobox 1	+27.5	+26.9	+23.9
Prune2	Prune homolog 2 (Drosophila)	+24.5	+17.5	+27.0
Psat1	Phosphoserine aminotransferase 1	+12.3	+13.3	+11.1
S100a4	S100 calcium binding protein A4	+13.4	+12.5	+10.1
Slc30a4	Solute carrier family 30 (Zinc transporter), member 4	+20.6	+11.7	+16.2
Snora17	Small nucleolar RNA, H/ACA box 17	+18.3	+11.5	+26.6

The 25 transcripts identified from comparative analyses of global gene expression between five murine cancer cell lines (LLC, MC38, AE17, B16F10, and PANO2 cells) and benign airway epithelial cells by alphabetic order.

^*ΔGE, fold-difference in gene expression between Kras-mutant tumour cells and benign airway epithelial cells. Ccl2 was the most consistently over-represented transcript across all three cell lines examined. LLC, C57BL/6 Lewis lung carcinoma; MC38, C57BL/6 colon adenocarcinoma; AE17, C57BL/6 malignant pleural mesothelioma.