Figure 3. Exosomes secretion prevents ATM/ATR-dependent DDR.

Pre-senescent TIG-3 cells were transfected with two different sets of validated siRNA oligos indicated at the top of the panel for twice at 2 day intervals. These cells were then subjected to western blotting using antibodies shown right (a) or to cell proliferation analysis (b). Tubulin was used as a loading control (a). The representative data from three independent experiments are shown. Error bars indicate mean±s.d. of triplicate measurements.