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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Adv Healthc Mater. 2016 Dec 20;6(1):10.1002/adhm.201601185. doi: 10.1002/adhm.201601185

Figure 1.

Figure 1

In vitro characterization of alginate hydrogels, and their effects on hMSC osteogenic differentiation. (A) Stress-time curves of human hematomas subjected to compression testing. Curves depict stress relaxation of hematomas held at 15% strain. Inset shows time to 50% of the initial stress in these curves. (B) Young’s modulus as determined by compression testing of slow and fast-relaxing alginate hydrogels. (Student’s t-test, n=4) (C) Time to 50% stress relaxation at 15% initial strain for slow and fast-relaxing alginate hydrogels. (Student’s t-test, n=4) (D) Extent of gel contraction after culture with encapsulated hMSCs for two weeks. (Student’s t-test, n=4) (E) Representative von Kossa staining for matrix mineralization between slow and fast-relaxing gels with encapsulated hMSCs in osteo-inductive medium after two weeks. Scale bar represents 300 μm. (F) Representative pseudo-colored EDS elemental maps for slow and fast-relaxing gels with encapsulated hMSCs in osteo-inductive medium after two weeks. Orange depicts phosphorous and marks phosphate deposition, while green depicts carbon.