Table 4.
Vancomycin parameter estimates from the population PK model
| Parameter | Typical Value (%RSEa) | Inter-individual Variability %CV (%RSEa) |
|---|---|---|
| CL (L/h/80 ml/min), θCL | 3.12 (6.1) | 47.5 (13.2) |
| V1 (L/70 kg), θV1 | 43.5 (22.8) | 92.2 (40.4) |
| Q (L/h), θQ | 8.66 (51.6) | NE |
| V2 (L/70 kg), θV2 | 45.8 (19.1) | 81.5 (30.1) |
| Residual Error Parameter | ||
| σ2 1prop (%) | 23.2 (15.6) | |
CLclearance, V 1central volume of distribution, Q inter-compartmental clearance, V 2peripheral volume of distribution, σ 2 1prop proportional component of the residual error model, NE not estimated
a%RSE: percent relative standard error of the estimate = SE/parameter estimate * 100 (for variability terms this is the %RSE of the variance estimate)