Table 5.
Summary of vancomycin dose, estimated PK and PK-PD index parameters by baseline renal function
| Parametersa | Normal renal (>80 ml/min) (n = 67) |
Mild/moderate impairment (30–80 ml/min) (n = 53) |
Severe impairment (<30 ml/min) (n = 13) |
|
|---|---|---|---|---|
| Daily dose (mg/kg/day) | Mean (CV%) | 29.4 (36) | 23.2 (39) | 13.5 (58) |
| Median (range) | 28.6 (9.3–60.4) | 23.5 (8.2–53.0) | 11.6 (4.0–35.3) | |
| Clearance (CL, l/h) | Mean (CV%) | 5.7 (44) | 2.7 (38) | 1.0 (47) |
| Median (range) | 5.3 (0.8–11.3) | 2.8 (0.9–4.9) | 0.9 (0.3–2.0) | |
| AUC0–24 (μg·h/ml) | Mean (CV%) | 428 (38) | 524 (33) | 548 (22) |
| Median (range) | 404 (153–1121) | 484 (226–1203) | 516 (384–777) | |
| AUC0–24/MIC | Mean (CV%) | 458 (58) | 490 (41) | 524 (26) |
| Median (range) | 394 (76–1320) | 472 (108–1203) | 514 (309–777) | |
| Trough concentration (Cmin, μg/ml) | Mean (CV%) | 11.9 (54) | 16.0 (40) | 18.4 (25) |
| Median (range) | 10.6 (3.2–38.6) | 15.0 (6.7–42.5) | 18.0 (12.4–28.7) |
CV% coefficient variation in percentage, AUC 0–24 area under the curve over 24 h, MIC minimum inhibitory concentration
aThe average values during the treatment period in each individual were used for summary statistics