Table 2.
Top loci (P < 1.0 × 10− 5) associated with clinical fracture in African-American women.
| Top SNP in regiona | Chr | Positionb | Effect allele | EAFc | P | Effect ratiod (95% CIe) | Directions of effectf | N | I2(g) | Nearest gene |
|---|---|---|---|---|---|---|---|---|---|---|
| rs12775980 | 10 | 29,899,862 | A | 0.03 | 4.0 × 10− 8 | 2.12 (1.61, 2.79) | ++++− | 10,302 | 0 | SVIL (intron) |
| rs11872467 | 18 | 9,838,002 | A | 0.11 | 1.1 × 10− 6 | 2.29 (1.64, 3.20) | ?++++ | 2147 | 0 | RAB31 (intron) |
| rs10931422 | 2 | 190,084,680 | T | 0.07 | 2.5 × 10− 6 | 1.62 (1.33, 1.97) | ++++− | 10,302 | 0 | SLC40A1(nearby) |
| rs2275731 | 10 | 16,566,846 | A | 0.37 | 3.5 × 10− 6 | 1.36 (1.21, 1.53) | +−+++ | 10,302 | 67.9 | PTER (intron) |
| rs7113850 | 11 | 24,151,165 | G | 0.78 | 4.7 × 10− 6 | 1.54 (1.29, 1.83) | +++++ | 10,302 | 0 | LUZP2 (nearby) |
| rs12284314 | 11 | 75,116,572 | C | 0.21 | 5.0 × 10− 6 | 1.39 (1.21, 1.60) | ++−+− | 10,302 | 43.7 | MOGAT2 (intron) |
| rs7547923 | 1 | 180,976,245 | A | 0.03 | 6.5 × 10− 6 | 3.22 (1.94, 5.39) | ?++++ | 2147 | 35.8 | NPL (nearby) |
| rs12606715 | 18 | 65,062,093 | C | 0.42 | 8.0 × 10− 6 | 1.32 (1.18, 1.49) | +++++ | 10,302 | 0 | DOK6 (nearby) |
| rs6792156 | 3 | 48,629,942 | C | 0.46 | 9.3 × 10− 6 | 1.34 (1.17, 1.53) | +++++ | 10,302 | 0 | COL7A1 (nearby) |
a
SNP with lowest P-value within a 1 megabase region. See corresponding LocusZoom plots.
b
HapMap phase 2, release 22, build 36.
c
EAF = effect allele frequency.
d
Effect ratio refers to the meta-analyzed hazard ratios (from WHI and Health ABC) and odds ratios (from BioVu, CHS and JoCoOa).
e
CI = confidence interval.
f
WHI, HealthABC, CHS, BioVU, JoCoOA.
g
I2 = heterogeneity statistic.