Fig. 2.

Boxplots of the D-spacing distribution of the collagen fibrils located in trabecular bundles obtained for Sham, OVX + Veh, OVX + ALN, and OVX + CatKI groups. There are significant differences in the degree of animal-to-animal variability across treatments in trabecular bone (p = 0.02, likelihood ratio Chi square test). The animal-to-animal variance for the OVX + Veh treatment was marginally significant (p = 0.074). Both of the drug treatments introduced significant animal-to-animal variability in the bundle D-spacing (p < 0.01). There were two ALN animals that did not contain any fibrils that were coded as being in a bundle. One of those two animals had both sheet and oblique microstructures and the other animal only had oblique microstructures.