Fig. 2.

Effects of DRTF or E₂ on body weights and organ indices in OVX rats. (A) The body weights of the animals were recorded every 2 weeks during the experimental period. Values are mean ± SD (n = 8), *p < 0.05, **p < 0.01compared with sham; ^#p < 0.05, ^##p < 0.01 compared with OVX. (B) Uteri were isolated and weighed after euthanization, the uterus index was determined as the uterus weight divided by body weight. Values are mean ± SD (n = 8), *p < 0.001, ***p < 0.001 compared with sham; ^{^^^}p < 0.001 compared with E₂ treatment. (C) HE dyed sections of rat uteri obtained from (a) Sham, (b) OVX, (c) E₂, (d) DRTF25, (e) DRTF75, and (f) DRTF225 treated animals. (D) The heart, liver, spleen, lung, kidney, brain and thymus were isolated and weighed after the animals were sacrificed and the organ index was represented as organ weight divided by body weight.