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. 2016 Oct 15;194(8):1015–1025. doi: 10.1164/rccm.201608-1690ST

Table 2.

Selecting a Conceptual Framework for Implementation Science

Example of Specific Implementation Research Question Family of Questions Overall Goal Theory or Conceptual Framework (Examples)
What are the barriers to and enablers of implementing asthma clinical pathways in community hospitals? What are the behavioral and contextual barriers to and enablers of implementation? What component(s) should be included in the implementation strategy to overcome the barriers and enhance the enablers? Develop an implementation strategy to translate research into practice Behavior Change Wheel (59); PRECEDE (60)
What components should be included in a strategy to implement lung-protective ventilation in patients with ARDS?
What are the barriers to and enablers of implementing a behavioral weight loss program into a sleep apnea clinic?
       
Can best practices for asthma clinical pathway implementation be adapted to community hospitals? What factors explain whether or not an implementation strategy is effective? Can a successful implementation strategy or health program be adapted to a different setting? Understand what influences implementation outcomes Consolidated Framework for Implementation Research (48); Theory of Diffusion (32)
What factors reduced the adoption of lung-protective ventilation in patients with ARDS by respiratory therapists?
Can a general behavioral weight loss program be adapted for use in a sleep apnea clinic?
       
Does a strategy to implement asthma clinical pathways improve asthma management in community hospitals? Is an implementation strategy effective in translating research into practice? Evaluate implementation strategy using process and clinical outcomes RE-AIM (49); PRISM (61); Logic Model (62)
What is the effect of an implementation strategy to use lung-protective ventilation in patients with ARDS on mortality and ventilator duration?
Does adding a behavioral weight loss program into sleep apnea care reduce cardiovascular risk?

Definition of abbreviations: ARDS = acute respiratory distress syndrome; PRECEDE = Predisposing, Reinforcing, and Enabling Causes in Education Diagnosis and Evaluation; PRISM = Practical, Robust Implementation and Sustainability Model; RE-AIM = Reach, Effectiveness, Adoption, Implementation, Maintenance.