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Reduction of tPA-induced MMP-2 and MMP-9 activations by isoflurane pretreatment (A) The level of active MMP-2 was evaluated using an activity assay kit. Isoflurane pretreatment blocked MMP-2 activation by tPA during OGD/R conditions. (B) Increased MMP-9 activation in the tPA-treated group after OGD/R, was significantly reduced in the isoflurane-pretreated group. ***p< 0.001 vs. OGD/R + tPA group, the one-way ANOVA (means ± SEM, active MMP-2 (ng/mL) (n=3),active MMP-9 (ng/mL) (n=6))
