Table 2.
pD2 values and maximal responses (Emax) elicited by thromboxane analogue, U-46619 in aortic segments from different mouse groups.
| U-46619 | pD2 | Emax (mg) |
|---|---|---|
| SD group | 8.01 ± 0.05 | 1649 ± 111 |
| HFD group | 7.64 ± 0.05* | 1196 ± 87* |
| HFD+Bif group | 7.75 ± 0.06 | 1531 ± 135# |
SD group: control mice receiving a standard diet; HFD group: obese mice receiving a high-fat diet; HFD+Bif group: obese mice receiving HFD and a daily dose of 1 x 109 CFU B. pseudocatenulatum CECT 7765 by gavage during 14 weeks.
pD2, -log mol/L of substance causing 50% of the maximal contraction; Emax, maximal contraction. Data are expressed as mean ± standard error of the mean of each mouse group (n = 8 per group).
Significant differences were established by ANOVA and post hoc Bonferroni's test at *p < 0.05 versus SD group and #p < 0.05 versus HFD group.