Table 3.
pD2 values and maximal responses (Emax) elicited by noradrenaline in the absence and in the presence of L-NAME in mouse aortic segments from the three studied groups.
| Noradrenaline | pD2 | Emax (mg) |
|---|---|---|
| SD | 8.01 ± 0.06 | 388 ± 70$ |
| SD + L-NAME | 8.11 ± 0.03 | 895 ± 60 |
| HFD | 8.03 ± 0.05 | 214 ± 24*$ |
| HFD + L-NAME | 8.00 ± 0.03 | 465 ± 33 |
| HFD+Bif | 8.06 ± 0.06 | 301 ± 27#$ |
| HFD+Bif + L-NAME | 7.89 ± 0.03 | 476 ± 33 |
SD group: control mice receiving a standard diet; HFD group: obese mice receiving a high-fat diet; HFD+Bif group: obese mice receiving HFD and a daily dose of 1 x 109 CFU B. pseudocatenulatum CECT 7765 by gavage during 14 weeks.
pD2, -log mol/L of substance causing 50% of the maximal contraction; Emax, maximal contraction; L-NAME, NG-nitro-L-arginine methyl ester. Data are expressed as mean ± standard error of the mean of each mouse group (n = 8 per group).
Significant differences were established by ANOVA and post hoc Bonferroni's test at *p < 0.05 versus SD group, #p < 0.05 versus HDF $p < 0.05 compared with L-NAME treatment in the same group.