Table 2.

Effects of Matrix-M on gene expression (relative gene expression versus untreated control) in cultures of porcine monocytes, lymphocytes and monocyte-derived dendritic cells (MoDC)

Target name	Lymphocytes 3 daysa		Monocytes 1 daya	MoDC 5 daysa
	Matrix-M 6 hb	Matrix-M 3 daysb	Matrix-M 6 hb	Matrix-M 6 hb	Matrix-M 5 daysb
	n = 8c	n = 8c	n = 10c	n = 6c	n = 6c
IL-1β	2.0	9.6*	3.3*	–	–
IL-6	< >	3.9	2.1	< >	10.2*
TNF-α	2.5	< >	< >	–	–
CXCL8	2.4*	5.9**	3.2**	< >	< >
IL-12p40	2.6*	2.6*	nd	–	–
IL-17A	0.3	27.8*	nd	–	–
IFN-γ	< >	4.8*	nd	–	–
IL-10	0.2*	0.4*	< >	–	–
TGF-β	< >	< >	–	–	–
IFN-α	< >	< >	< >	< >	3.8*
IFN-β	nd	nd	nd	< >	2.8
IFITM3	< >d	< >d	< >	< >d	< >d
SPP1	< >d	< >d	< >e	< >d	0.2d
STING	< >d	< >d	–	< >d	< >d
TLR2	0.4**	0.2	< >	0.3*	0.2*

< >, gene not affected, i.e. 0.5 < FC < 2.

nd not detected; too few samples showed any expression of the gene of interest to allow FC calculation, – not analysed.

* p < 0.05 and ** p < 0.01 for difference in expression between Matrix-M treated samples and medium control (i.e. FC ≠ 1); Wilcoxon matched-pairs signed rank test.

^aTotal culture time.

^bMatrix-M exposure time.

^cUnless otherwise indicated.

^d n = 4.

^e n = 6.