Table 4.
Genes with alleles specific to cluster 2 isolates
| Locus | Functional category | Number of mutation | Number of non-synonymous mutation |
|---|---|---|---|
| NEIS0370 (carA) | Metabolism (pyrimidine and alanine, aspartate and glutamate) | 1 (bp 1057) | 1 (T → A)a |
| NEIS0422 (metK) | Metabolism (cysteine and methionine metabolism) | 1 (bp 726) | 0 |
| NEIS0529 | Metal ions transport (zinc/manganese) | 1 (bp 363) | 0 |
| NEIS1091 (cysl) | Metabolism (sulfite reductase) | 1 (bp 1021) | 1 (P → T)a |
| NEIS1237 (cmk) | Metabolism (pyrimidine) | 1 (bp 611) | 1 (I → T)a |
| NEIS1379 (dnaZX) | Metabolism/DNA processing | 1 (bp 1774) | 1 (G → S)a |
| NEIS1460 | Putative metabolism (Glucose-6-Phosphate 1-Dehydrogenase_bact motif) | 1 (bp 402) | 0 |
| NEIS1741 (murC) | Metabolism (D-glutamine/D-Glutamate, peptidoglycan biosynthesis) | 1 (bp 397) | 1 (A → S)a |
| NEIS1804 | putative role in toxicity (associated with Maf Genomic islands MGI-1 scheme pubmlst) | 1 (bp 868) | 1 (F → V) |
| NEIS0132 (rplC) | Genetic information processing (ribosomal protein) | 1 (bp 22) | 1 (C → R)a |
aChange in the chemistry properties of the AA side chains