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LPS upregulates GFAP expression and GFAP signal in hippocampus in both PRNP genotypes. Mean GFAP expression was investigated by transcriptome analysis (Illumina HiSeq 2000) on RNA extracted from the hippocampus. GFAP immunohistochemistry (IHC) shows increased GFAP signal in the molecular layer, subgranular layer, and hilus after LPS administration. Activated astrocytes have more distinct primary and secondary processes. ×200 magnification. LPS, n = 16. Saline, n = 10
