Table 1.
Choroid plexus DEGs between PRNP genotypes after LPS treatment
| Gene ID | Symbol | Gene name | Log2 ratio | Top functions |
|---|---|---|---|---|
| 100860813 | MHC II | HA25 | 1.80 | Antigen presentation (extracellular pathway) |
| 102178155 | FTSJ1 | FtsJ RNA methyltransferase homolog 1 | 1.53 | Methyltransferase |
| 102169982 | ISG15 | ISG15 ubiquitin-like modifier | 0.99 | ISGylation, innate immunity |
| 102189650 | ANK3 | Ankyrin 3 | 0.75 | Cell motility, activation, proliferation, |
| 102187800 | UBB | Ubiquitin B | 0.73 | Targeting of proteins for degradation |
| 102184593 | SPOCK2 | SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 2 | 0.68 | Extracellular matrix structure |
| 102183219 | BGN | Biglycan | −0.60 | Extracellular matrix structure, innate immunity |
| 102188061 | ATP5E | ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit | −0.63 | Catalyzes ATP synthesis, oxidative phosphorylation |
| 102185420 | COL24A1 | Collagen type XXIV alpha 1 chain | −0.66 | Extracellular matrix structure |
| 102172487 | CP | Ceruloplasmin | −0.66 | Acute phase protein, ferroxidase enzyme |
| 102169556 | CXCL12 | C-X-C motif chemokine ligand 12 | −0.67 | Chemoattractant, innate immunity |
| 102172637 | LECT1 | Leukocyte cell derived chemotaxin 1 | −0.69 | Promotes chondrocyte growth, inhibit angiogenesis |
| 102170107 | ATP5J2 | ATP synthase, H+ transporting, mitochondrial Fo complex subunit F2 | −0.70 | Catalyzes ATP synthesis, oxidative phosphorylation |
| 102181355 | PCOLCE | Procollagen C-endopeptidase enhancer | −0.75 | Collagen precursor peptidase activator |
| 100860756 | OGN | Osteoglycin | −0.76 | Growth factor activity |
| 102179198 | TNC | Tenascin C | −0.81 | Extracellular matrix structure |
| 102182694 | CXCL14 | C-X-C motif chemokine ligand 14 | −0.81 | Chemoattractant, immunomodulatory |
| 102177419 | NDUFA1 | NADH:ubiquinone oxidoreductase subunit A1 | −0.85 | Component of the respiratory chain, mitochondria |
| 102191086 | COCH | Cochlin | −1.03 | Extracellular matrix, pro-inflammatory, cytokine regulatory |
| 102187830 | COL17A1 | Collagen type XVII alpha 1 chain | −1.04 | Hemidesmosome component |
| 102189939 | ATP5I | ATP synthase, H+ transporting, mitochondrial Fo complex subunit E | −1.58 | Catalyze ATP synthesis, oxidative phosphorylation |
| 100860915 | ASIP | Agouti signaling protein | −2.14 | Paracrine signaling, pigmentation |
| 102180584 | MHC I | BOLA class I histocompatibility antigen, alpha chain BL3-7 | −2.32 | Antigen presentation (cytosolic pathway) |
| 102169975 | PRNP | Prion protein | −2.80 | Unknown, cytoprotective |
| 102176354 | HP | Haptoglobin | −3.25 | Acute phase protein, bind hemoglobin |
Differential expression analysis was performed by comparing LPS-treated PRNP Ter/Ter vs. PRNP +/+ (log2 ratio ± 0.59 and q < 0.05). n = 15