Table 2.
Upregulated and downregulated genes in the hippocampus after LPS challenge
| Log2 ratio, LPS vs. saline | |||||
|---|---|---|---|---|---|
| Gene ID | Symbol | Gene name | PRNP +/+ | PRNP Ter/Ter | Top functions |
| 102185230 | IFI6 | Interferon alpha inducible protein 6 | 1.19* | −0.05 | Regulation of apoptosis |
| 100860873 | CXCL10 | C-X-C motif chemokine ligand 10 | 3.37* | 3.07* | Chemoattractant |
| 102187851 | CXCL9 | C-X-C motif chemokine ligand 9 | 2.93* | 2.65* | Chemoattractant |
| 102185477 | TGM2 | Transglutaminase 2 | 1.25* | 1.36* | Unclear, involved in phagocytosis |
| 102189939 | ATP5I | ATP synthase, H+ transporting, mitochondrial Fo complex subunit E | 0.53 | 0.76* | Catalyze ATP synthesis |
| 102190069 | GFAP | Glial fibrillary acidic protein | 0.34 | 0.62* | Cell communication, mitosis, BBB function |
| 102178715 | HOPX | HOP homeobox | 0.35 | 0.65* | Unknown |
| 102188072 | MT2 | Metallothionein-2 | 0.29 | 0.91* | Metal-binding, neuroprotection |
| 102188618 | MT1A | Metallothionein-1A | 0.58 | 1.40* | Metal-binding, neuroprotection |
| 100860878 | SLC14A1 | Solute carrier family 14 member 1 | 0.54 | 1.59* | Membrane transport (urea) |
| 102186073 | AQP4 | Aquaporin 4 | −0.61* | −0.31 | Membrane transport (water) |
| 102175716 | MYO10 | Myosin X | −0.66* | −0.53 | Motor molecule, bind actin |
| 102186825 | COL9A2 | Collagen type IX alpha 2 chain | −0.43 | −0.64* | Extracellular matrix structure |
Differential expression analyses were performed by comparing the LPS groups to the saline control group of the matching genotype. Italic values indicate a true differential expression. LPS, n = 15. Saline, n = 10
*log2 ratio ±0.59, q < 0.05