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. 2017 May 22;16:93. doi: 10.1186/s12943-017-0660-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Presence of PIK3CA mutations confers resistance in colony-forming assays and wound-healing upon MET inhibition. a, colony-forming assays (left: relative colony quantification; right: representative images). b, wound-healing assays. Cell contours were enhanced for clarity using the Paint.NET software. P-values represent comparisons between treatment conditions and vehicle-treated controls