TABLE 3.

Comparison of ELISA and neutralization titers before and after depletion of anti-CD4 antibodies from sera collected after the fourth immunization

Group	Vaccine antigen	ELISA titer				Neutralization titer (IC90)a
		CD4		gp120		MN		1357-0b
		Undepleted	Depleted	Undepleted	Depleted	Undepleted	Depleted	Undepleted	Depleted
1	gp120 (DNA)	3,200	3,200	100,000	100,000	80	46	10	<46
		1,600	1,600	400,000	400,000	160	46	<10	<46
		1,600	1,600	50,000	50,000	<10	<40	20	<40
		6,400	6,400	400,000	400,000	40	44	<10	<44
2	gp120-CD4D12 (DNA)	300,000	1,000	400,000	400,000	>1,280	51	160	<51
		1,638,400	1,000	100,000	100,000	320	<57	160	<57
		6,553,600	1,000	100,000	100,000	640	<67	320	<67
		1,638,400	1,000	100,000	100,000	160	<48	20	<48

^aIC₉₀, 90% inhibitory concentration, expressed as the reciprocal of the serum dilution in which 90% or more of the viral antigen production was inhibited relative to production in untreated viral growth control wells.

^bCCR5-utilizing primary isolate.