Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 May 23;11:289. doi: 10.3389/fnins.2017.00289

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Brown and Pearson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Adult neurons are born continuously in the adult flatworm from a large population of adult stem cells. (A) Fluorescent in situ hybridization (FISH) of planarian adult stem cells (neoblasts) as marked by piwi-1. Neoblasts span the entire length of the body except for the region anterior to the eyes. (B) BrdU pulse chase experiments demonstrating the continuous nature of adult neurogenesis in the planarian. Worms were fed BrdU food (25 mg/mL) 2 days in a row and chased for 2 and 3 weeks. BrdU was detected and combined with FISH of the brain marker chat to mark acetylcholine neurons. Panels are representative single slice confocal planes. (C) Adult stem cells surround the Ventral-Medial (VM) and Dorsal-Lateral (DL) zones of the brain, two putative neurogenic zones. These stem cells are the likely source of new neurons during adult neurogenesis.