Table 1.
Treatment, outcome and follow-up of 76 patients with Candida species PJI.
| Reference/ author |
Treatment Antifungal treatment Surgical treatment |
Outcome | Follow-up (months) | |
|---|---|---|---|---|
| 51/Zhu Y | Amphotericin B Voriconazole |
NR | Cure | 3 |
| 52/Reddy KJ | Fluconazole Amphotericin B ICS |
TEA | Cure | 24 |
| 46/Artiaco S | Fluconazole Miconazole |
Drainage of abscess | Cure | 12 |
| 37/Lidder S | Amphotericin B | TEA | Cure | 24 |
| 34/Ueng SWN | Fluconazole Amphotericin B ICS |
TEA | Cure | NR |
| 34/Ueng SWN | Fluconazole | TEA | Cure | NR |
| 34/Ueng SWN | Fluconazole | TEA | Cure | NR |
| 34/Ueng SWN | Fluconazole Amphotericin B ICS |
TEA | Cure | NR |
| 34/Ueng SWN | Fluconazole Amphotericin B ICS |
TEA | Cure | NR |
| 34/Ueng SWN | Fluconazole | RA | NR | NR |
| 34/Ueng SWN | Fluconazole | RA | NR | NR |
| 34/Ueng SWN | Fluconazole | RA | Dead | NR |
| 42/Anagnostakos K | Caspofungin | TEA | Cure | 28 |
| 42/Anagnostakos K | Fluconazole | TEA | Cure | 22 |
| 42/Anagnostakos K | Fluconazole | TEA | Cure | 70 |
| 42/Anagnostakos K | Fluconazole | TEA | Cure | 15 |
| 42/Anagnostakos K | Fluconazole | TEA | Cure | 36 |
| 42/Anagnostakos K | Fluconazole | TEA | Cure | 47 |
| 47/Bartalesi F | Voriconazole Caspofungin + amphotericin B Amphotericin B |
TEA | Cure | 48 |
| 35/Wu MH | Fluconazole Amphotericin B ICS |
RA | Cure | 12 |
| 11/ Kelesidis T | Fluconazole | NR | Cure | 12 |
| 12/Graw B | Fluconazole | TEA | Cure Dead (UD) |
240 |
| 13/Bland CM | Liposomal amphotericin B + micafungin + fluconazole | RA | NR | NR |
| 43/Dumaine V | Caspofungin + flucytosine Fluconazole + flucytosine |
RA Arthrodesis |
Cure | 15 |
| 53/Lejko-Zupanc T | Liposomal amphotericin B + fluconazole Caspofungin |
RA | Cure | 36 |
| 54/Fabry K | Voriconazole (3 days) Oral voriconazole (7 months) |
NR | Cure Dead (UD) |
24 |
| 27 (/2004) Gaston G | Voriconazole Amphotericin B Amphotericin B ICS |
RA | Amputation | 6 |
| 48/Lazzarini L | Amphotericin B | RA | Cure | 48 |
| 15/Wyman J | Fluconazole Amphotericin B |
TEA | Cure | 36 |
| 16/Phelan DM | Amphotericin B Ketoconazole Fluconazole |
TEA | Cure | 73 |
| 16/Phelan DM | NR | TEA | Cure | 51 |
| 16/Phelan DM | Amphotericin B Fluconazole |
TEA | Cure | 70 |
| 16/Phelan DM | Fluconazole Fluconazole ICS |
TEA | Cure | 17 |
| 55/Açkgöz CZ | Fluconazole | RA Arthrodesis |
Cure | 7.5 |
| 38/Bruce ASW | Fluconazole Fluconazole IB |
TEA | Cure | 84 |
| 38/Bruce ASW | Fluconazole Fluconazole IB |
TEA | Cure Dead (UD) |
48 |
| 56/Marra F | Fluconazole Amphotericin B ICS |
RA (twice) |
E. coli infection NR final outcome |
NR |
| 44/Merrer J | Fluconazole | NR | Cure Dead (UD) |
11 |
| 36/Yang SH | Fluconazole | TEA | Cure | 48 |
| 39/Ramamohan N | Amphotericin B + 5-flucytosine | TEA | Cure | 24 |
| 57/Badrul B | Fluconazole | TEA | MRSA infection Cure |
60 |
| 49/Wada M | Fluconazole | NR | Cure | 36 |
| 17/Brooks DH | Amphotericin B Fluconazole |
NR | Cure | 24 |
| 40/Selmon GPF | Amphotericin B Itraconazole + fluconazole |
OEA | Cure | 48 |
| 18/Simonian PT | Ketoconazole | NR | Cure | 72 |
| 50/Fukasawa N | Fluconazole | NR |
P. aeruginosa infection Cure |
24 |
| 19/Cushing RD | Fluconazole | NR | Cure | 12 |
| 58/Nayeri F | 5-flucytosine + amphotericin B 5-flucytosine + itraconazole |
RA | Cure | 22 |
| 20/Hennesy MJ | Amphotericin B 5-flucytosine |
TEA | Cure | 24 |
| 21/Cardinal E | Amphotericin B | RA | Cure Dead (UD) |
NR |
| 21/Cardinal E | Amphotericin B | RA | Cure Dead (UD) |
12 |
| 21/Cardinal E | Fluconazole | RA | Cure | 6 |
| 22/White A | Fluconazole Amnphotericin B Itraconazole |
RA | Cure | 24 |
| 23/Tunkel AR | Amphotericin B Ketoconazole Fluconazole |
RA | Amputation | NR |
| 41/Paul J | Amphotericin B + 5-fluorocytosine Ketoconazole |
RA Arthrodesis |
Cure | 24 |
| 24/Evans RP | Amphotericin B | TEA | Cure | 24 |
| 24/Evans RP | Amphotericin B | TEA |
S. aureus infection Cure |
60 |
| 25/Darouiche RO | Amphotericin B | RA | Cure | 8 |
| 25/Darouiche RO | Amphotericin B | RA | Cure | 1.5 |
| 25/Darouiche RO | Amphotericin B Ketoconazole |
RA Arthrodesis |
Cure | 36 |
| 25/Darouiche RO | Amphotericin B | RA | Cure | 5 |
| 26/Lambertus M | Amphotericin B | RA |
S. epidermidis infection Cure |
24 |
| 26 /Lambertus M | Amphotericin B Ketoconazole |
RA Arthrodesis |
Cure | 14 |
| 27/Levine M | Amphotericin B | RA Arthrodesis |
Cure | 24 |
| 28/Iskander MK | Amphotericin B Ketoconazole |
RA Arthrodesis |
Cure | NR |
| 29/Koch AE | Amphotericin B 5-flucytosine Ketoconazole |
RA Arthrodesis |
Cure | 21 |
| 30/Lim EVA | Amphotericin B | RA | Cure | 28 |
| 31/Younkin S | 5-fluocytosine + amphotericin B | TEA | Cure | 24 |
| 32/Lichtman EA | Amphotericin B Ketoconazole |
RA | Cure | 3 |
| 33/Goodman JS | Amphotericin B | RA | Cure | NR |
| 33/Goodman JS | Amphotericin B | TEA RA Arthrodesis |
Cure | 12 |
| 10/MacGregor RR | Amphotericin B + 5-flucytosine | RA | Cure | 12 |
| 45/Jenny JY | Caspofungine + 5-flucytosine Voriconazole + 5-flucytosine |
OEA | Cure | 24 |
| 45/Jenny JY | Voriconazole + 5-flucytosine Fluconazole + 5-flucytosine |
OEA | Cure | 36 |
| 9/Cobo F | Caspofungin Fluconazole |
No surgical treatment | Cure | 6 |
| PR/Cobo F | Caspofungin 14 days Fluconazole (expected 6 months) |
No surgical treatment | No relapse | 3 |
UD: unrelated disease; NR: not reported; PR: present report; TEA: two-stage exchange arthroplasty; RA: Resection arthroplasty; OEA: one-stage exchange arthroplasty
ICS: impregnated cement spacer; IB: impregnated beads